mutation myoo-TAY-shun Your browser does not support the audio element. [ English ] Definition 1. A change or transition. 2. A organ stop that sounds the desired pitch and adds an additional pitch or pitches. It will typically include an octave and often another pitch that is an overtone in the harmonic series. Share Share on Facebook (opens in a new tab) Share on X (opens in a new tab) Last Updated: 2016-06-05 20:28:59